个人简介：
成睿，2023年获得哈尔滨工业大学博士学位。同年，加入云南大学担任助理研究员及硕士生导师，专注于生物信息学领域的研究。目前，以第一作者/通讯作者（含共同）在Oncogene、Science China Life Sciences、Briefings in Bioinformatics、npj Vaccines等期刊发表SCI论文10余篇；主持国家自然科学基金青年项目C类(30万元)、国家科技重大专项子任务（200万元）、云南大学-生物医学应用转化研究发展基金（200万元）、云南省实验室重大专项（300万元）、云南大学青年培优引进人才科研启动项目（50万元）。
招生专业：
生物信息学硕士
生物与医药（专硕）
研究方向：
生物信息学与免疫信息学
代表性研究成果：
1.Qingqin Wu#, Huajie Hu#, Liuyu Qin#, Xupu Ma#, Bohao Chen, Xuan Li, Yanli Chen, Lei Xing, Mei Yang, Chunmei Li, Zijie Scott Zhang*, Xuerong Pan* & Rui Cheng*. Refined phenotyping of vaccine responses reveals transcriptomic determinants of neutralizing antibody heterogeneity. npj Vaccine 2026
2.Rong Wang, Huajie Hu, Yanli Chen, Wei Yang, Chunmei Li, Mengjie Chen*, Rui Cheng*, Zijie Zhang*. Decoding vaccine-induced immunity: From systems vaccinology to artificial intelligence–driven precision vaccines. hLife 2025
3.Yuemiao Zhang#,* , Lan Wang#, Junze Wu#, Na Wan#, Xingzi Liu#, Miaomiao Lin, Jingmei Li, Jingyu Wang, Jingyi Wu, Jiawen Peng, Shaoqing Dang, Tong Xie, Hongyu Yang, Xin Zhang, Yang Li, Xujie Zhou, Lijun Liu, Sufang Shi, Timothy T. Lu, Peter K. Wung, David James Haddon, Yanni Jiang, Naren Gaowa, Jicheng Lv, Zijie Zhang, Chunmei Li*, Rui Cheng*, Hong Zhang*. Single-cell transcriptomic analysis of the terminal ileum identifies BCMA as a therapeutic target in IgA nephropathy. hLife 2026 （Cover article）
4.Rui Cheng#, Lixing Xiao#, Wenyang Zhou#, Xiyun Jin, Zhaochun Xu, Chang Xu, Pingping Wang, Meng Luo, Mengyun Wang, Kexin Ma, Huimin Cao, Yan Huang, Xiaoyu Lin, Fenglan Pang, Yiqun Li, Qinghua Jiang*. A pan-cancer analysis of alternative splicing of splicing factors in 6904 patients. Oncogene. 2021 Sep;40(35):5441-5450.
5.Rui Cheng#, Xiaoman Zheng#, Yingmei Wang#, Xing Ma#, Xin Liu#, Wenjun Xu, Mengyun Wang, Yuanpeng Gao, Xupeng Xing, Chuan Zhou, Hongzheng Sun, Zekun Guo, Fusheng Quan, Jun Liu*, Song Hua*, Yongsheng Wang*, Yong Zhang* & Xu Liu*. Modification of alternative splicing in bovine somatic cell nuclear transfer embryos using engineered CRISPR-Cas13d. SCIENCE CHINA Life Sciences. 2022 May 5.
6.Rui Cheng#, Zhaochun Xu#, Huimin Cao, Xiyun Jin, Wenyang Zhou, Meng Luo, Lixing Xiao, Qinghua Jiang*. Identification of alternative splicing-derived tumor-specific antigens for mRNA vaccine development. Briefings in Bioinformatics. 2022 Mar 10;23(2):bbab553.
7.Rui Cheng#, Xiaoman Zheng#, Yingmei Wang#, Mengyun Wang, Chuan Zhou, Jun Liu, Yong Zhang, Fusheng Quan* and Xu Liu*. Genome-wide analysis of alternative splicing differences between oocyte and zygote. Biology of Reproduction. 2020 Apr 24;102(5):999-1010.
8.Mengyun Wang#, Rui Cheng#, Hongjuan He, Zhengbin Han, Qiong Wu*. N4-acetylcytidine of Nop2 mRNA is Required to the Transition of Morula-to-Blastocyst. Cellular and Molecular Life Science. 2023 Sep 28;80(10):307.
9.Lixing Xiao#, Haoxiu Sun#, Rui Cheng#, Rongrong Yang, Xiyun Jin, Zhaochun Xu, Yideng Cai, Yuexin Yang, Fenglan Pang, Guangfu Xue, Pingping Wang*, Qinghua Jiang*, Huan Nie*. Functional Requirement of Alternative Splicing in Epithelial-Mesenchymal Transition of Pancreatic Circulating Tumor. Molecular Therapy: Nucleic Acid. 2024 Jan 24;35(1):102129.
10.Haoran Yu#, Yue Zhao#, Rui Cheng#, Mengyun Wang, Xin Hu, Ximeijia Zhang, Xiangqi Teng, Hongjuan He, Zhengbin Han, Xiao Han, Ziwen Wang, Bingjing Liu, Yan Zhang*, Qiong Wu*. Silencing of maternally expressed RNAs in Dlk1-Dio3 domain causes fatal vascular injury in the fetal liver. Cellular and Molecular Life Science. 2024 Oct 9;81(1):429.
11.Lixing Xiao #, Guoying Zou #, Rui Cheng #, Pingping Wang, Kexin Ma, Huimin Cao, Wenyang Zhou, Xiyun Jin, Zhaochun Xu, Yan Huang, Xiaoyu Lin, Huan Nie*, Qinghua Jiang*. Alternative splicing associated with cancer stemness in kidney renal clear cell carcinoma. BMC Cancer. 2021 Jun 15;21(1):703.
12.Yingmei Wang#, Xiaoman Zheng#, Rui Cheng#, Jing Han#, Xing Ma, Wenjun Xu, Lu Gao, Anmin Lei, Jun Liu, Fusheng Quan, Yong Zhang*, Xu Liu*. Asymmetric expression of maternal mRNA governs first cell-fate decision. Faseb Journal. 2021 Nov;35(11):e22006.
