罗静教授

个人简介：

罗静，博士，教授，云南大学生物交叉技术创新中心PI。NSFC重大研究计划集成项目、重大项目课题等主持人；在Science, Nature, Sci Adv, PNAS, Sci Bull, Brief Bioinform, Heredity等杂志发表学术文章近60篇。曾获云南省自然科学一等奖，德国马普学会博士后奖学金。现任云南省遗传学会副理事长和云南省水产学会副理事长，云南高原土著鱼研究院科技副总，培养或联合培养的学生曾获中国首届博士后创新人才计划、中国科协首届青年人才托举工程博士生专项计划等支持，并获得省级硕博优秀论文等荣誉。致力于水产领域的产学研结合，主要研究方向为多倍化物种基因组多样性，脊椎动物多倍化基因组学，人工杂交多倍化鱼类的繁育与组学特征，鱼类的基因组演化及其生态适应性以及生物信息学及组学、AI for水产等领域的相关软件的研发。基于多年在脊椎动物复杂基因组学和生物信息学领域的深耕，结合云南大学生物交叉技术创新中心发展方向，利用AI与生物医药结合，聚焦AI驱动的生物医药质量智能评价技术与平台建设。

招生专业：

生物化学与分子生物学博士
生物信息学硕士
生物与医药博士、硕士——生物化学与分子生物学方向

研究方向：

1、生物医药质量评价新方法与新技术的开发研究
基于多年在脊椎动物复杂基因组学和生物信息学领域的深耕，结合云南大学生物交叉技术创新中心发展方向，利用AI与生物医药结合，聚焦AI驱动的生物医药质量智能评价技术与平台建设，整合质谱、结构、活性等多源质量数据与深度学习、迁移学习等 AI 模型，解析复杂生物医药产品的质量属性关联；通过 AI 驱动的多源数据融合分析，构建可预测、可解释的质量评价新模式，实现产品质量实时监控与智能决策。
2、AI与数据平台驱动的复杂基因组研究与智能化应用
聚焦于将人工智能与多组学大数据技术相结合，推动复杂基因组演化规律的解析与智能化养殖管理系统的建设。利用跨组学数据（单细胞空间组学、基因组学、转录组学、表观组学、代谢组学等）整合与比较基因组分析，揭示多倍化事件对基因功能分化和适应性演化的影响。通过深度学习与大模型技术，研发影像识别与行为监测系统，精准识别水生动物的微小行为变化，为水产养殖的智能化、精准化提供技术支撑，推动种业创新与生态安全管理。
3、杂交物种基因组演化与生态安全研究
围绕云南高原冷水性鱼类与跨境流域土著鱼类资源，系统研究杂交多倍化物种的基因组变化规律的同时，注重生态安全边界。通过多组学与AI辅助选择，解析杂交优势（生长、抗病、饲料转化率、环境耐受等）的遗传基础；在严格的生态风险评估与准入管理下，形成标准化、可复制的良种繁育与养殖模式，建设规模化示范基地，推动云南特色渔业跨越式发展与产业升级。

代表性成果：

主持或承担的科研项目：
1.NSFC重大项目“远缘杂交鱼类分子遗传规律研究”中的课题3 “远缘杂交二倍体和三倍体鱼优势性状的关键功能基因及调控机制”2023.01-2027.12
2.云南省兴滇人才计划“云岭学者”配套项目 “远缘杂交鱼类的遗传规律解析及云南土著异源多倍体鱼类的资源开发利用” 2025.01-2029.12
3.云南省西南联合研究生院科技专项-基础研究和应用基础研究重大项目“人工远缘杂交鱼类及天然异源多倍化鱼类的遗传规律解析研究”2025.01-2027.12
4.国家基金重大计划集成项目“异源杂交鲫鲤体系不同世代基因组初期变化及其遗传稳定性研究”2017.01-2019.12
5.NSFC-云南省联合基金项目“高原湖泊水质变化过程中鲫鱼复合种群体多样性变化及其生态适应性” 2020.01-2023.12
6.国家自然科学基金重大研究计划培育项目“异源杂交多倍化鲫鲤初期不同世代的遗传变化规律研究”2014.01-2016.12
7.云南大学“双一流”建设联合专项-重大项目“高度复杂基因组格局下远缘杂交品种生长优势性状的深度学习探究”2023.03-2026.02
8.国家自然科学基金面上项目“鲤科多倍化鱼类HOX基因簇演化研究” 2009.01-2011.12
9.重点研发项目“高黎贡地区野生动物全景动态监测体系建设与安全评估示范”中的专题，高黎贡山鱼类群体遗传多样性及其种群历史动态研究”2022.11-2025.10
10.国家自然科学基金地区科学基金项目“异源杂交多倍化鲫鲤特有性状的转录组及后转录组水平变化规律研究”2014.01-2017.12
11.重点项目“异源四倍体鲫鲤及其亲本的分子遗传关系研究” 2010.01-2013.12
12.973计划项目“中国-喜马拉雅地区生物多样性演变和保护研究”2008.10-2010.03

代表性论文：（#共同第一作者，*共同通讯作者）

1.Chuanshuai Xie#, Zitu Ma#, Chaowei Zhou#, Kexin Ma#, ..., Jing Luo, Daniel J. Macqueen, Axel Meyer*, Haiping Liu*, Luohao Xu*. (2026). Chromosomal fusions trigger genome rediploidization in a young autopolyploid vertebrate. Nature. DOI :10.1038/s41586-026-10439-1
2.Zhifan Guo#, Jinxin Li#, Adeniyi C. Adeola#, Xueyan Jiang#, Juntao Ma#, Jian Xiao#...., Jing Luo*, Olivier Hanotte*, Yaping Zhang*, Yan Li#*. (2026) Deciphering the Evolution Pattern of Structural Variations Overlapped With Repetitive Sequence during Cattle Evolution. Advanced Science. 9: e23333.SCI https://doi.org/10.1002/advs.202523333
3.Chong Wang #, Xuedie Gu#, Guoliang Lin #, ..., Yan Li*, Xiaoyong Chen*, Jing Luo*. (2026) Haplotype-Resolved Genome Sheds Light on Polyploidy and Altitudinal Adaptation in Freshwater Fishes. Zoological Research. DOI: 10.24272/j.issn.2095-8137.2025.354
4.Jian Xiao#, Xiaolong Tu#, Wenhua Yuan#, ..., Jinxiu Li*, Jing Luo*, Yaping Zhang*, Yan Li*. (2025) NOCT, a potential domestication gene impacting circadian rhythm and behaviors during dog domestication. Zoological Research.47(2):444-458. SCI https://doi.org/10.24272/j.issn.2095-8137.2025.270
5.Kaizhuang Jing#, Tingchu Wei, Xuedie Gu, Guoliang Lin, Lin Liu*, Jing Luo*. (2025) Deep learning reveals determinants of transcriptional infidelity at nucleotide resolution in the allopolyploid line by goldfish and common carp hybrids. Briefings in Bioinformatics, 26(3): bbaf260. SCI https://doi.org/10.1093/bib/bbaf260
6.Guoliang Lin#, Zhiru Huang#, Tingsong Yue#, Jing Chai#, Yan Li#, ..., Yaping Zhang*, Zijie Zhang*, Wei Zhou*, Jing Luo* (2024) Puzzle Hi-C: An accurate scaffolding software. PLoS One. 19(7): e0298564. SCI https://doi.org/10.1371/journal.pone.0298564.
7.Yan Li#*, Sheng Wang#, Zhe Zhang#, Jing Luo#, Guoliang Lin#, Weidong Deng#, Zhifan Guo#, …, Yaping Zhang* (2023) Large-Scale Chromosomal Changes Lead to Genome-Level Expression Alterations, Environmental Adaptation, and Speciation in the Gayal (Bos frontalis). Molecular Biology and Evolution. 40(1). SCI 2023;40(1): msad006. https://doi.org/10.1093/molbev/msad006
8.Yuan Chen#, Tingsong Yue#, Guoliang Lin#, Xi Luo, Huimin Yang, Robert W. Muphy, Siyuan Gao*, Jing Luo* (2023) Transcriptome analysis confirms aquatic animals have less risk by carrying on human respiratory viruses. Reprod Breed. 3(4):161-168. https://doi.org/10.1016/j.repbre.2023.09.002.
9.Jing Luo#, Jing Chai#, Yanling Wen#, Min Tao#, Guoliang Lin#, ..., Peng Xu*, Jue Ruan*, Z. Jeffrey Chen*, Shaojun Liu*, Xuemei Lu*, Yaping Zhang* (2020) From asymmetrical to balanced genomic diversification during rediploidization: subgenomic evolution in allotetraploid fish. Science Advances 6(22), SCI https://doi.org/10.1126/sciadv.aaz7677.
10.Peng Xu#*, Jian Xu#, Guangjian Liu#, ..., Jing Luo, Jing Chai, Hanyuan Zhang, Hui Wang, Chuanju Dong, Wenkai Jiang, Xiaowen Sun. (2019) The allotetraploid origin and asymmetrical genome evolution of the common carp Cyprinus carpio. Nature Communications, 10: 4625, SCI https://doi.org/10.1038/s41467-019-12644-1.
11.Fanqin Yin#, Wenfu Liu#, Jing Chai#, Bin Liu, Robert W. Murphy, Jing Luo*. CRISPR/Cas9 Application for Gene Copy Fate Survey of Polyploid Vertebrates. Frontiers in Genetics. (2018) 9:260 SCI https://doi.org/10.3389/fgene.2018.00260.
12.Wei Zhou#, Ruilin Li#, Shuo Yuan, ChangChun Liu, Shaowen Yao, Jing Luo*, Beifang Niu* (2017) MetaSpark: a Spark-based distributed processing tool to recruit metagenomic reads to reference genomes. Bioinformatics, 1-3. SCI https://doi.org/10.1093/bioinformatics/btw750.
13.Guoliang Lin#, Jing Chai#, ..., Wei Zhou*, Jing Luo* (2016) VennPainter: A Tool for the Comparison and Identification of Candidate Genes Based on Venn Diagrams. PLos One, 11(4): e0154315. SCI https://doi.org/10.1371/journal.pone.0154315.
14.Shaojun Liu#*, Jing Luo#, Jing Chai#, Li Ren#, Yi Zhou#, Feng Huang#, Xiaochuan Liu#, ..., Axel Meyer*, Yaping Zhang* (2016) Genomic incompatibilities in the diploid and tetraploid offspring of the goldfish x the common carp cross. Proc Natl Acad Sci USA 113(5), 1327-1332. SCI https://doi.org/10.1073/pnas.1512955113.
15.Jing Chai#, Yuebo Su#, ..., Jing Luo* (2015) The gap in research on polyploidization between plants and vertebrates: model systems and strategic challenges. Science Bulletin 60(17), 1471-1478. SCI https://doi.org/10.1007/s11434-015-0879-8.
16.Jing Luo#, Yun Gao#, ..., Yaping Zhang* (2014) Tempo and mode of recurrent polyploidization in the Carassius auratus species complex (Cypriniformes, Cyprinidae). Heredity 112(4):415-427, SCI https://doi.org/10.1038/hdy.2013.121.
17.Wei Ma#, ZH. Zhu#, ..., Yaping Zhang*, Jing Luo* (2014) Allopolyploidization is Not So Simple: Evidence from the Origin of the Tribe Cyprinini (Teleostei: Cypriniformes). Current Molecular Medicine 14(10):1331-1338, SCI https://doi.org/10.2174/1566524014666141203101543.
18.Jing Wang#, Xiaoyun Wu#, Ziming Chen#, ..., Ruiguang Zan*, Jing Luo* (2013) Molecular phylogeny of European and African Barbus and their West Asian relatives in the Cyprininae (Teleostei: Cypriniformes) and orogenesis of the Qinghai-Tibetan Plateau. Chinese Science Bulletin 58(31):3738-3746, SCI https://doi.org/10.1007/s11434-013-5878-z.
19.Shanjin Wu#, Jing Luo#, ..., Bisong Yue*, Yaping Zhang*. (2013) Ecological genetics of Chinese rhesus macaque in response to mountain building: all things are not equal. PLos One 8(2): 55315-55341. SCI https://doi.org/doi:10.1371/journal.pone.0055315
20.Zhihui Li, ..., Yaping Zhang, Jing Luo* (2011) Polyploidization and epigenetics. Chinese Science Bulletin 56(3), 245-252. SCI https://doi.org/10.1007/s11434-010-4290-1.
21.李智慧, 逯翔, 高云, 刘少军, 陶敏, 肖蘅, 乔云倩, 张亚平, 罗静* (2010) 物种多倍化与表观遗传学, 科学通报, 35期, 3358-3366. https://doi.org/10.1360/csb2010-55-35-3358.
22.Jing Luo#, Peter F. Stadler, Shunping He, Axel Meyer* (2007) PCR survey of hox genes in the goldfish Carassius auratus auratus. Journal of Experimental Zoology (Mol Dev Evol) 308B(3): 250-258, SCI https://doi.org/10.1002/jez.b.21144.
23.Jing Luo#*, Michael Lang, Walter Salzburger, Nicol Siegel, Kai N. Stolting, Axel Meyer* (2006) A BAC library for the goldfish Carassius autratus auratus (Cyprinidae, Cypriniformes). Journal of Experimental Zoology, 306B(6): 567-574. SCI https://doi.org/10.1002/jez.b.21112.
24.Jing Luo#*, M. Sanetra, M. Schartl, Axel Meyer*. (2005) Strong Reproductive Skew Among Males in the Multiply Mated Swordtail Xiphophorus multilineatus (Teleostei). Journal of Heredity, 96(4): 346-355. SCI https://doi.org/10.1093/jhered/esi042.
25.Jing Luo#，Dongming Yang, Hitoshi Suzuki, Yingxiang Wang, Weijen Chen, Kevin L. Campbell, Yaping Zhang*. (2004) Molecular phylogeny and biogeography of Oriental voles: genus Eothenomys (Muridae, Mammalia). Molecular Phylogenetics and Evolution, 33(2): 349-362. SCI https://doi.org/10.1016/j.ympev.2004.06.005.
26.Peter Savolainen#*, Yaping Zhang, Jing Luo, Joakim Lundeberg, Thomas Leitner. (2002) Genetic Evidence for an East Asian Origin of Domestic Dogs. Science, 298(5598): 1610-1613. SCI https://doi.org/10.1126/science.1073906.
27.罗静#, 杨君兴, 张亚平* (2000) 鱼类多样性的遗传基础, 动物学研究, 02: 158-164.
28.罗静#, 王蕊芳, 熊郁良, 吴世芳, 王婉瑜, 李东升, 朱绍文, 张亚平* (2000) 团花锦蛇、绿锦蛇和三索锦蛇的核型及Ag-NORs, 应用与环境生物学报, 6(3): 232-236. https://doi.org/10.3321/j.issn:1006-687X.2000.03.008.
29.罗静#, 张亚平* (2000) 分子钟及其存在的问题, 人类学学报, 19(02): 151-159. https://www.anthropol.ac.cn/CN/Y2000/V19/I02/151.
30.Jing Luo#, Yaping Zhang*, Chunling Zhu, Wuhan Xiao, Shunyou Huang (1999) Genetic diversity in crucian carp (Carassius auratus). Biochemical Genetics, 37(9-10): 267-279. SCI https://doi.org/10.1023/A:1018751008848.
31.罗静#, 张亚平*, 朱春玲, 肖武汉 (1999) 鲫鱼遗传多样性的初步研究, 遗传学报, 01: 28-36.
32.罗静#, 张亚平, 朱春玲, 肖武汉, 黄顺友 (1999) 鲫鱼(Carassius auratus)遗传多样性研究, 云南大学学报(自然科学版), S3: 226-227.
33.罗静#, 王蕊芳, 李东升, 熊郁良，张亚平* (1998) 菜花烙铁头核型的初步报道, 动物学研究, 06: 80-81.

代表性专著

1. Ziming Chen#, Jing Luo#, et al. (2010) Subterranean Fishes of China, Biology of Subterranean Fishes, E.Trajano, M.E. Bichuette, B.G. Kapoor, Science Publishers, CRC Press, 397-413. https://doi.org/10.1201/EBK1578086702. (Co-first authors)
2 《深度学习在生物信息学中的研究与应用》周维 罗静 主编 科学出版社 2022

代表性专利

“基于多特征的CTCF介导染色质环预测方法” 罗静, 彭文钰, 于小娟, 林国亮, 颜培祺.
地方标准
罗静, 项晴雪, 赵杰玉, 蒋传娣, 于虹漫, 严晖, 黄典一, 冷云, 刘仪莲, 殷琦丰, 殷立京,赵忠. 滇池高背鲫种质特征基因分子鉴定技术规程. DB53/T 1370—2025